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XPRIZE Healthspan

$101 million prize purse; per-recipient maximum not established · XPRIZE / Hevolution Foundation

XPRIZE Healthspan is a prize programme from XPRIZE / Hevolution Foundation for Teams worldwide that register under the competition rules and can demonstrate an intervention restoring muscle, cognition, and immune function in older adults Current status: closed; Seven-year competition, 2023–2030; primary registration is closed and late registration is discretionary rather than an open deadline. Award economics: $101 million prize purse; per-recipient maximum not established; dilution/equity: none.

Tier 1prizeglobalhealthnon-dilutive

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Key facts

FunderXPRIZE / Hevolution Foundation
Amount$101 million prize purse; per-recipient maximum not established
Decision timeQualification, semifinals, finals application and human study/testing; final award depends on demonstrated functional restoration under the rules.
EligibilityGlobal teams of individuals or organizations could enter. New entry now requires discretionary late registration and qualification; only qualified semifinalists could submit the April 2026 finals application.
RestrictionsExtensive rules, clinical-study evidence, safety/accessibility requirements, biomarkers and formal platform submissions; this is a high-burden prize, not a grant for ordinary operating costs. Dilution/equity: none.
Statusclosed

Always confirm on the official page before applying — dates and terms change.

Application process

  1. Register a team or request discretionary late registration
  2. Complete qualifying submission and judging
  3. Advance through semifinals
  4. Qualified semifinalists submit a finals application
  5. Run the required study and demonstrate restoration of muscle, cognitive and immune function

Background

XPRIZE / Hevolution Foundation operates XPRIZE Healthspan. The official-source pass separates the currently actionable opportunity from historical cohorts and separates per-recipient value from headline program envelopes. The official page lists first milestone winners announced in May 2025 and a qualified-teams book.

How the application really works

Register a team or request discretionary late registration → Complete qualifying submission and judging → Advance through semifinals → Qualified semifinalists submit a finals application → Run the required study and demonstrate restoration of muscle, cognitive and immune function

Tips

Watch out for

Track record

Qualified-team and milestone-winner materials are published; no simple acceptance percentage is stated.

Frequently asked questions

Is this opportunity actionable now?
closed. Seven-year competition, 2023–2030; primary registration is closed and late registration is discretionary rather than an open deadline.
What is the real per-recipient economic value?
$101 million prize purse; per-recipient maximum not established. Award minimum: not published. Dilution/equity: none.
Which jurisdictions and applicants are eligible?
Global teams of individuals or organizations could enter. New entry now requires discretionary late registration and qualification; only qualified semifinalists could submit the April 2026 finals application.
How does selection work?
Register a team or request discretionary late registration; Complete qualifying submission and judging; Advance through semifinals; Qualified semifinalists submit a finals application; Run the required study and demonstrate restoration of muscle, cognitive and immune function. Qualification, semifinals, finals application and human study/testing; final award depends on demonstrated functional restoration under the rules.
What appears to win?
A safe, accessible therapeutic completed in one year or less; Restoration of muscle, cognitive and immune function by at least 10 years in people aged 50–80; Robust clinical and biomarker evidence under finals rules
What burden or follow-on should I expect?
Extensive rules, clinical-study evidence, safety/accessibility requirements, biomarkers and formal platform submissions; this is a high-burden prize, not a grant for ordinary operating costs. Milestone and final prizes within one competition; no automatic follow-on grant.

Related grants

XPRIZECompetition-specific purses: USD 119 million Water Scarcity, USD 101 million Healthspan, USD 11 million Wildfire and USD 5 million Quantum Applications; payment goes to milestone and final winners rather than every entrant. · XPRIZE Foundation (competition-specific title sponsors, e.g. Google Quantum AI)XPRIZE Water Scarcity$119 million prize purse; per-recipient maximum varies by track and round · XPRIZE / Mohamed bin Zayed Water InitiativeXPRIZE Quantum Applications$5 million prize purse; per-recipient maximum not established · XPRIZE / Google Quantum AIXPRIZE Wildfire$11 million prize purse; $3.5 million first prize in each main track · XPRIZE / PG&E / Gordon and Betty Moore FoundationNIH SBIR/STTR (Small Business Programs / SEED)Phase I guideline up to USD 400,000 and Phase II up to USD 2.15 million; approved waiver topics may reach about USD 700,000 Phase I and USD 3 million Phase II. · National Institutes of Health (NIH) — HHSDARPA SBIR/STTRTypical DARPA Phase I: USD 250,000 over about six months; Phase II: USD 1.8 million over 24-36 months; Enhancement may add up to USD 500,000 in 1:1 matching funds. · Defense Advanced Research Projects Agency (DARPA) — DoD

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